. 2016 Aug 9;125(2):207–214. doi: 10.1289/EHP376

Table 2.

Interactive effects of single nucleotide polymorphisms with occupational exposure to low molecular weight agents or irritants on current adult-onset asthma.

Chr	Gene	SNP	Reference/effect allele	EAF^a	Cases/controls n/n	Marginal effect		Interaction–CC
Chr	Gene	SNP	Reference/effect allele	EAF^a	Cases/controls n/n	OR	p-Value	OR	p-Value
1	PLA2G4A	rs932476	A/G	0.35	463/2,136	1.25	0.0036	0.64	0.0050
2	PLA2R1	rs2667026	A/G	0.83	463/2,136	0.89	0.2354	1.77	0.0050
11	RELA^b	rs931127	A/G	0.43	462/2,135	1.17	0.0350	1.61	0.0014
11	RELA	rs7949980	C/T	0.51	463/2,133	1.07	0.3421	1.56	0.0030
14	PRKD1^b	rs1958980	A/G	0.67	463/2,136	1.08	0.3344	0.64	0.0042
14	PRKD1	rs11847351	A/G	0.67	463/2,133	1.08	0.3429	0.64	0.0043
14	PRKD1	rs1958987	C/T	0.68	459/2,127	1.07	0.3609	0.64	0.0050
17	PRKCA	rs6504453	C/T	0.35	462/2,134	1.04	0.6086	0.63	0.0032
Notes: CC, case–control; Chr, chromosome; EAF, effect allele frequency; OR, odds ratio; SNP, single nucleotide polymorphism. ^aCalculated in controls. ^bThe two SNPs near RELA are in moderate linkage disequilibrium (LD) with r² = 0.65, whereas the three SNPs in PRKD1 are in strong LD (r² > 0.8).