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Mcmdc2Gt/Gt ovarian histology reveal lack of oocytes. (A) H&E staining of adult females demonstrates the absence of follicles (and thus, oocytes) in Mcmdc2Gt/Gt ovaries. (B) H&E staining of 24-day-old wild-type or Mcmdc2Gt/Gt females. Wild-type ovaries contain abundant primordial follicles (black arrows) and primary follicles (white arrows), while no primordial follicles are apparent in the Mcmdc2Gt/Gt ovaries. Mcmdc2Gt/Gt ovaries also appear smaller than wild type.
