Figure 7.

Model for the role of Grh in regulating gene expression during development. Both maternally and zygotically supplied Grh bind to the regulatory regions of hundreds of genes throughout multiple stages of development. Grh likely marks cis-regulatory regions that are subsequently bound by additional transcription factors (TF) that mediate the stage-specific Grh function. Maternally supplied Grh acts predominantly as a transcriptional repressor in stage 5 embryos. Zygotically supplied Grh can function as a transcriptional repressor and activator during embryogenesis or in the larvae.