Figure 5.

(A) Driver allele frequency trajectories, effective fitness advantage of resistance allele, and establishment probabilities under recessive, codominant, and completely dominant driver fitness costs in our standard model. $\pi \left(t\right)$ is not visible in the dominant scenario as it is very close to zero. (B) Threshold frequencies $x_0$ at which a resistance allele needs to be present to have the given establishment probability in the case of a completely dominant driver with cost $s_{\mathrm{d}0}.$ (C) Replacement of driver by resistance allele. Shown is the deterministic frequency trajectory of a driver allele in our standard model and its replacement by a resistance allele from the SGV that was present as a single copy (solid line) or 100 copies (dashed line) when the driver was introduced. (D) Time until resistance allele and driver allele reach 50% population frequency in (C) when varying driver cost $s_{\mathrm{d}0}.$ Once driver cost reaches $s_{\mathrm{d}0}\approx 0.25$ in our model, the driver will be outpaced by the resistance allele before it can reach 50%.