Table 1. Description of all model parameters.

Parameter	Standard model	Description
$x_{\mathrm{d}}\left(t=0\right)$	10−5	Introduction frequency of driver allele
$c$	0.9	Cleavage rate in driver/wild-type heterozygotes
$\delta$	10−6	Fraction of cleavage events resulting in resistance allele by NHEJ
$\mu$	10−8	Rate at which wild-type alleles mutate into resistance alleles
$s_{\mathrm{d}0}$	0.1	Fitness cost of driver/wild-type heterozygotes
$s_{\mathrm{dr}}$	0.1	Fitness cost of driver/resistance heterozygotes
$s_{\mathrm{r}0}$	0.0	Fitness cost of resistance/wild-type heterozygotes
$s_{\mathrm{dd}}$	0.2	Fitness cost of driver homozygotes
$s_{\mathrm{rr}}$	0.0	Fitness cost of resistance homozygotes
$N_{\mathrm{e}}$	106	Variance effective population size
$N$	106	Census population size