Table 1. Autosomal SNP-based heritability and G × Sex interaction in WTCCC diseases.
| Disease | Heritabilitya | G × Sex Interactiona | |
|---|---|---|---|
| M h2g (SE) | F h2g (SE) | h2gxs (SE) | |
| ASb | 0.11 (0.04) | 0.15 (0.07) | 0.01 (0.05) |
| BD | 0.18 (0.08) | 0.22 (0.06) | −0.01 (0.06) |
| CAD | 0.25 (0.09) | 0.50 (0.22) | 0.12 (0.11) |
| CDb | 0.14 (0.06) | 0.17 (0.04) | 0.03 (0.05) |
| HT | 0.18 (0.21) | 0.73 (0.17)*** | 0.19 (0.17) |
| MSb | 0.17 (0.02) | 0.17 (0.02) | 0.06 (0.01)**** |
| RAb | 0.20 (0.11) | 0.08 (0.05) | 0.03 (0.06) |
| T1Db | 0.14 (0.06) | 0.08 (0.06) | 0.04 (0.06) |
| T2D | 0.31 (0.12) | 0.37 (0.15) | −0.06 (0.12) |
h2g, heritability; SE, standard error. **** P < 0.0005, *** P < 0.001.
a
Empirical P-value for difference between M and F h2g: estimation based on 1000 permutations.
b
HLA locus was tested separately from the rest of the autosomes.