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Inhibition of mouse COX-2 mutants by indomethacin or compound 12.
| Enzymes | Indomethacin IC50 (μM)a |
Compound 12 IC50 (μM)a |
|---|---|---|
| wt mCOX-2 | 0.25 | 0.29 |
| wt oCOX-1 | 0.04 | > 4 |
| V349L | 4.0 | > 4 |
| V523I | 0.45 | 1.1 |
| S530A | 0.22 | 1.5 |
| R120Q | 0.30 | 0.09 |
| Y355F | > 4 | > 4 |
IC50 values are average determinations from three experiments. The experimental method is described in the Supporting Information.
