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. 2017 Jan 25;4(1):84–96.e6. doi: 10.1016/j.cels.2016.11.015

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of RNAi Screen for Perturbations in the Relationship between YAP Localization and Cell Shape

(A) Difference between observed YAP ratios and YAP ratios predicted from morphological features (YAP_diff).

(B) Total YAP intensities as a function of YAP_diff. Blue circles: average of each control well (n = 554 wells, n = 273-3382 cells/well). Red crosses: average of replicate siRNA-transfected wells. Dashed lines: 2 SDs of control wells.

(C) Glyphs represent average normalized shape features and subcellular YAP intensities (see inset). Relative positions correspond to average YAP_diff (y axis) and numbers of cells per well (x axis).