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. 2017 Feb 3;11:6. doi: 10.3389/fncir.2017.00006

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Copyright © 2017 Smith-Hicks, Cai, Savonenko, Reeves and Worley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Repeated daily exposure to enriched environment “A” disrupts fidelity of reactivation in CA1 of Ts65Dn mice. (A) Behavioral timeline. (B) Solid arrow indicates double positive neurons expressing Arc transcript in nucleus and cytoplasm, while dashed arrow indicates neuron with nuclear only Arc transcript. (C) Scatter plot showing the mean percent ± SEM of Arc positive neurons in area CA1 of WT and Ts65Dn (Ts) mice. The percent of neurons with intranuclear Arc foci is significantly greater in Ts65Dn CA1, p = 0.03, while fewer Ts65Dn neurons are double positive for Arc, p = 0.004. Five WT mice with a total of 656 neurons were counted and 4 Ts65Dn mice with a total of 495 neurons were counted.