Table 2.

Summary of the lncRNA genes successfully edited by the CRISPR/Cas9 system.

miRNA	Chromosomal location	Cells/Animals tested	Results	Reference
UCA1	Chr19	Human HCT-116 cells	After >5.6 kb in length for the UCA1 gene was edited, UCA1 RNA levels were reduced by about 90%	Ho et al. (2015)
MALAT1 or NEAT1	Chr11	Human cell lines: HEK293T, HCT-116, Hela and IMR90	Up to 98%reduction in MALAT1 RNA expression was achieved after the upstream and major promoters in the MALAT1 gene were deleted	Aparicio-Prat et al. (2015)
LncRNA-21A	Chr8	Human HCT-116 cells	475 bp for the lncRNA-21 A gene was targeted, wild-type lncRNA-21A was completely lost	Ho et al. (2015)
AK023948	Chr8	Human MCF-7 cells	The AK023948 gene was knocked out	Ho et al. (2015)
LncRNA Rian	Chr12	Mice	23 kb fragment in the lncRNA Rian gene was deleted, and a Rian knock-out mouse model with heritability of this large fragment deletion was established	Han et al. (2014)

Abbreviations: UCA1, urothelial cancer associated 1; MALAT1, metastasis associated lung adenocarcinoma transcript 1; NEAT2, noncoding nuclear-enriched abundant transcript 2.