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. 2017 Feb 3;8:91. doi: 10.3389/fimmu.2017.00091

Figure 1.

Figure 1

Real-time quantitative PCR analyses of HDFs stimulated with IL-17A (100 ng/ml) and TNF-α (10 ng/ml) alone or together for 24 h. The results demonstrate that both IL-17A and TNF-α induce significant increases in IL-6, IL-8, and CXCL-1 mRNA expression and IL-17A/TNF-α stimulation have additive or synergistic effect on IL-6, IL-8, and CXCL-1 mRNA expression. Additionally, IL-17A induces the mRNA expression of TNFR-2 and TNF-α induces IL-17RA and IL-17RC expression on HDFs. The data (fold change) are from one representative experiment performed in triplicate, repeated three times with similar results. HDFs, human dermal fibroblasts. Statistical significance indicated: *P < 0.05, **P < 0.01, ***P < 0.001.