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. 2004 Nov 17;101(48):16813–16818. doi: 10.1073/pnas.0407697101

Fig. 5.

Fig. 5.

Bv8 or EG-VEGF increases circulating leukocytes in mice and increases peripheral cells and spleen-derived colony forming units after 5-FU injury. Peripheral leukocyte (A) and absolute neutrophil (B) counts in animals treated with Bv8, EG-VEGF, GM-CSF, or control LacZ. Leukocyte (C) and neutrophil (D) counts in 5-FU-injured animals are shown. Bv8, EG-VEGF, GM-CSF, or control LacZ was administered 12 h before cytotoxin. (E) Spleen cell number in control, LacZ, Bv8, and Fltsel mice at day 10 after 5-FU. (F) Colony formation for 1 × 104 spleen cells from control, LacZ, Bv8, and Fltsel mice. Representative experiments are shown; n = 6–10 mice per group. *, P ≤ 0.05.