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Lethality of rHEP-Flury or rearranged viruses for suckling mice. (A) The LD50 was calculated from mortality among groups of 12 mice inoculated IC with five serial, 10-fold dilutions of virus. The LD50 was analyzed for statistical significance by one-way ANOVA. Asterisks denote statistical differences (∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ∗∗∗∗P < 0.0001) between different groups. (B) Onset of death after intracerebral inoculation of three serials.
