Figure 6.

Gal3 deficiency enhances infiltrating neutrophil anti-Candida functions. Gal3^+/+ and gal3^−/− mice were infected intravenously with 5 × 10⁵ of Candida. (A) Blood was collected from naïve mice (0) or mice at 18 h and 48 h after infection. The levels of CD11b expression on CD45⁺CD11b⁺Ly6G⁺ peripheral blood neutrophils are presented as mean fluorescence intensity (MFI). n = 3. (B,C) CD45⁺CD11b⁺Ly6G⁺ cells were sorted from total infiltrating cells in the kidney at 18 h after infection. The levels of reactive oxygen species (ROS) production (B) and their ability to kill (C) were determined. n = 3. Data are presented as mean ± SD. *p < 0.05, as analyzed by Mann–Whitney test.