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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Cancer Res. 2016 Nov 18;77(3):672–683. doi: 10.1158/0008-5472.CAN-16-1765

Figure 2. Primary tumor-associated stroma cultures secrete IL8 and IL6 in response to primary pancreatic cancer cell conditioned media.

Figure 2

A, micrograph demonstrating αSMA-positive (brown) desmoplasia associated with PC. Primary tumor-associated stromal cells (TAS) were cultured from PC specimens and PC cells were isolated and expanded from patient-derived xenografts. TAS cells were treated with conditioned media from primary PC cells (PCCM). B and C, IL8 and IL6 in PCCM as well as the supernatants resulting from 24 hours of exposure or not to 50% dilution of PCCM. D, Dose response of IL8 and IL6 expression by TAS upon exposure to PCCM. Bars represent mean ± S.E.M. *P < .05 compared to unstimulated (unstim) using the independent samples t test.