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. 2016 Jun 20;36(4):546–558. doi: 10.1038/onc.2016.227

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CRMP1 overexpression suppresses cell proliferation, migration and invasion capacities of DU145 prostate cancer cells. (a) Top: Immunoblot validation of CRMP1 expression in representative DU145-CRMP1 infectants. DU145-CRMP1 infectants expressed higher CRMP1 expression than the empty vector DU145-pBABE infectants and parental cells. Bottom: Representative images of DU145-CRMP1 and DU145-pBABE infectants. DU145-CRMP1 infectants appeared more cobblestone shaped and grew as clusters at subconfluence. Bars, 1 μm. (b) Cell counting assay. DU145-CRMP1 infectants proliferated at slower rates than the pBABE infectants. Brackets show the doubling time (hours). (c) Wound healing assay. DU145-CRMP1 infectants showed significantly slower migration capacity than the DU145-pBABE infectants. (d) Matrigel invasion assay. DU145-CRMP1 infectants exhibited significantly reduced invasion capacity than the DU145-pBABE infectants. Bars, 1 μm. *P<0.05; **P<0.01.