Table 2. Comparison of genetic mutational profiles of lung SCC based on smoking status.

Genes	Never-smoker (n = 12)	Ever-smoker (n = 14)	P value
TP53	9 (75.0)	13 (92.9)	0.306
PTEN	1 (8.3)	4 (28.6)	0.330
HRAS	7 (58.3)	10 (71.4)	0.683
KRAS	2 (16.7)	2 (14.3)	1.000
MLH1	2 (16.7)	0 (0.0)	0.203
MET	0 (0.0)	2 (14.3)	0.483
CDKN2A	0 (0.0)	4 (28.6)	0.100
SMARCB1	1 (8.3)	2 (14.3)	1.000
CTNNB1	1 (8.3)	1 (7.1)	1.000
FGFR3	0 (0.0)	2 (14.3)	0.483
BRAF	2 (16.7)	0 (0.0)	0.203
EGFR	3 (25.0)	2 (14.3)	0.635
KIT	3 (25.0)	6 (42.9)	0.429
NOTCH1	1 (8.3)	1 (7.1)	1.000
IDH2	1 (8.3)	1 (7.1)	1.000
PDGFRA	2 (16.7)	1 (7.1)	0.580
STK11	6 (50.0)	1 (7.1)	0.026
VHL	1 (8.3)	2 (14.3)	1.000
PIK3A	1 (8.3)	0 (0.0)	0.462
FBXW7	1 (8.3)	0 (0.0)	0.462
APC	0 (0.0)	2 (7.1)	0.483
RET	0 (0.0)	1 (8.3)	1.000
ATM	1 (8.3)	0 (0.0)	0.462
JAK3	1 (8.3)	0 (0.0)	0.462
AKT1	2 (16.7)	0 (0.0)	0.203
PTPN11	1 (8.3)	1 (7.1)	1.000

Values are presented as number (%).

SCC = squamous cell carcinoma.