Table 3. Comparisons of total serum IgE levels and induced sputum EOS in ACOS patients with different disease severity and healthy controls before and after treatment.

Group	Total serum IgE level, IU/mL			Induced sputum EOS%
	Before treatment	After treatment	P	Before treatment	After treatment	P
Control	110.6 ± 11.3	110.3 ± 11.8	0.840	4.0 ± 1.7	4.3 ± 1.5	0.161
Mild ACOS	215.0 ± 25.4*	109.7 ± 23.3	< 0.001	8.5 ± 3.6*	4.1 ± 2.8	0.003
Moderate ACOS	240.7 ± 14.3*	112.5 ± 16.7	< 0.001	14.7 ± 7.7*	4.2 ± 2.2	< 0.001
Severe ACOS	281.9 ± 42.5*	170.8 ± 40.2†	< 0.001	19.2 ± 8.4*	10.8 ± 3.7†	< 0.001
Extremely severe ACOS	348.2 ± 30.1*	186.1 ± 28.9†	< 0.001	27.8 ± 11.8*	11.9 ± 4.1†	< 0.001

IgE = immunoglobulin E, ACOS = asthma-chronic obstructive pulmonary disease overlap syndrome, EOS = induced sputum eosinophil counts.

^*P < 0.05, compared with the control group before treatment; ^†P < 0.05, compared with the control group after treatment.