Table 2. Summary of clinical findings in 9 patients with HCQ retinopathy.
No. | Sex/Age, yr | Diagnosis | CDVA (RE, LE) | Duration of use, mon | Total HCQ dose, g | Daily dose/RBW, mg/kg | SD-OCT | FAF | HVF | Pattern | Severity |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | F/48 | SLE, APLS | 20/20, 18/20 | 120 | 1,440 | 7.74 | Outer retinal thinning | NS | NS | Pericentral | Mild |
2 | F/33 | SLE | 20/20, 20/20 | 174 | 2,088 | 10.05 | Outer retinal thinning, CME | Abnormal | Field loss | Mixed | Severe |
3 | M/68 | RA | 20/25, 20/25 | 119 | 636 | 2.69 | Outer retinal thinning | Abnormal | Field loss | Mixed | Mod |
4 | F/74 | RA | 20/200, 20/50 | 76 | 912 | 8.33 | Outer retinal thinning | Abnormal | Field loss | Parafoveal | Severe |
5 | F/44 | Sjögren | 20/20, 20/20 | 93 | 558 | 3.70 | Outer retinal thinning | NS | Field loss | Parafoveal | Mild |
6 | F/60 | RA | 18/20, 18/20 | 116 | 768 | 4.38 | Outer retinal thinning | Abnormal | Field loss | Mixed | Severe |
7 | F/31 | SLE | 20/20, 20/20 | 119 | 786 | 3.52 | Outer retinal thinning | Abnormal | Field loss | Pericentral | Severe |
8 | F/39 | SLE | 20/20, 20/20 | 87 | 612 | 4.11 | Outer retinal thinning | NS | NS | Parafoveal | Mild |
9 | F/67 | SLE | 20/20, 18/20 | 125 | 888 | 4.08 | Outer retinal thinning | Abnormal | Field loss | Mixed | Mod |
CDVA = corrected distance visual acuity, RE = right eye, LE = left eye, RBW = real body weight, SD-OCT = spectral-domain optical coherence tomography, FAF = fundus autofluorescence, HVF = Humphrey visual field test, SLE = systemic lupus erythematosus, APLS = antiphospholipid antibody syndrome, RA = rheumatoid arthritis, IS/OS = inner segment/outer segment, CME = cystoid macular edema, NS = not significant, Mod = moderate.