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Model for MYC-mediated mRNA cap methylation of Wnt/β-catenin signaling pathway transcripts. MYC interacts with NuA4, composed of TRRAP, TIP60, and MRG15. MRG15 interacts with XPB, a component of TFIIH, bringing CDK7 in proximity to promoters and RNA Pol II. CDK7 phosphorylates S5 on the RNA Pol II CTD, which leads to the recruitment of RNGTT and RNMT/RAM. RNGTT caps nascent mRNA and RNMT mediates mRNA cap methylation.
