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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Cancer Res. 2016 Nov 22;77(3):742–752. doi: 10.1158/0008-5472.CAN-16-1817

Figure 5. Effects of cisplatin and PFT-µ on mitochondrial morphology.

Figure 5

Synaptosomes were isolated from the brains of animals treated with (A) PBS, (B) cisplatin, (C) PFT-µ, or (D) PFT-µ plus cisplatin for two 5-day cycles. (E) Mitochondrial length and (F) percentage of atypical mitochondria were quantified. Results are expressed as means ± SEM; n = 8. Bars without a common superscript are significantly different (P < 0.05). Oxygen consumption rates were analyzed in isolated synaptosomes using the Seahorse XFe 24 Analyzer. (G) Basal, (H) ATP production-related, (I) maximum, and (J) spare respiratory capacity were calculated. Results are expressed as means ± SEM; n = 8. Bars without a common superscript are significantly different (P < 0.05).