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. 2016 Dec 6;187(3):455–465. doi: 10.1111/cei.12898

Figure 1.

Figure 1

(a) Eosinophils from eosinophilic oesophagitis (EoE) patients and healthy controls (HC) suppress polyclonal T cell proliferation. Mixed lymphocyte reactions (MLRs) were performed for 6 days without or with eosinophils from EoE patients (n = 14) or from healthy individuals (n = 14). An eosinophil to peripheral blood mononuclear cell (PBMC) ratio of 1 : 1 was used. ***P = 0·0001 (Wilcoxon matched‐pairs signed‐rank test). (b) The suppressive capacity of eosinophils from EoE patients is inferior to that of healthy controls. Boxes with whiskers indicate medians, quartiles and min/max range. **P <0·01 (Mann‐Whitney test). (c) Eosinophils from EoE patients demonstrate the same T helper (Th) cell suppressive pattern as eosinophils from healthy controls. The fraction of interferon (IFN)‐γ‐, interleukin (IL)‐4 and IL‐17A‐producing Th cells in CD3/CD28‐stimulated PBMC cultures, with or without eosinophils from EoE patients (n = 2, squares) or from healthy individuals (n = 2, circles), was determined after 2 days of culture.