Table 1.
Demographic Information, N = 5,985 (HIV/HCV Co-infected)
| No Cirrhosis N= 3720 (%) |
Cirrhosis N=2265 (%) |
p value | |
|---|---|---|---|
|
| |||
| Age at HIV Diagnosis, years (mean) | 46 | 44 | <.0001 |
| Race | 913 (24.5) | 620 (27.3) | <.0001 |
| White/other/unknown | 2565 (68.9) | 1420 (62.7) | |
| Black | 242 (6.5) | 225 (9.9) | |
| Hispanic | |||
|
| |||
| Age at index, years | |||
| <40 | 513 (13.8) | 303 (13.4) | <.0001 |
| 40–50 | 1999 (53.7) | 1371 (60.5) | |
| >50 | 1208 (32.5) | 591 (26.1) | |
|
| |||
| Duration of follow-up, years | 8.5 | 3.5 | <.0001 |
|
| |||
| Outpatient encounters, year prior to index date (mean) | 14 | 16.5 | .0002 |
|
| |||
| Deyo Comorbidity Score* (w/o HIV) | |||
| 0 | 2760 (74.2) | 1851 (81.7) | <.0001 |
| 1 | 535 (14.4) | 255 (11.3) | |
| >2 | 425 (11.4) | 159 (7.0) | |
|
| |||
| Era of HIV Diagnosis | |||
| Pre-cART | 1035 (27.8) | 892 (39.4) | <.0001 |
| Early cART | 1353 (36.4) | 916 (40.4) | |
| Late cART | 1332 (35.8) | 457 (20.2) | |
|
| |||
| Ever cART* | 3189 (85.7) | 1802 (79.5) | <.0001 |
|
| |||
| CD4 Count * Cells/μL | |||
| <200 | 775 (20.8) | 638 (28.0) | <.0001 |
| 200–349 | 744 (20.0) | 520 (23.0) | |
| >350 | 2201 (59.2) | 1107 (48.9) | |
|
| |||
| CD4 Count Nadir* Cells/μL | |||
| ≤200 | 1943 (52.2) | 1178 (52.0) | 0.87 |
| >200 | 1777 (47.8) | 1087 (48.0) | |
|
| |||
| % Time HIV VL Undetectable* | |||
| 0–40% | 1550 (41.7) | 1373 (60.6) | <.0001 |
| 40–80% | 1091 (29.3) | 443 (19.6) | |
| >80% | 1079 (29.0) | 449 (19.8) | |
|
| |||
| HCV Genotype | |||
| 1 & 4 | 2185 (58.7) | 1136 (50.2) | <.0001 |
| 2 & 3 | 281 (7.5) | 137 (6.0) | |
| unknown | 1254 (33.7) | 992 (43.8) | |
|
| |||
| HCV Treatment* | |||
| None | 3321 (89.3) | 1940 (85.6) | <.0001 |
| No SVR | 290 (7.8) | 253 (11.2) | |
| SVR | 109 (2.9) | 72 (3.2) | |
|
| |||
| APRI Score (median) | |||
| Initial value | 0.47 | 0.6 | <.0001 |
| Most recent value | 0.46 | 2.23 | |
|
| |||
| HCC* | 22 (0.6) | 91 (4.0) | <.0001 |
|
| |||
| Max BMI*, kg/m2 | |||
| <30 | 2867 (77.1) | 1815 (80.1) | 0.005 |
| >30 | 853 (22.9) | 450 (19.9) | |
|
| |||
| ALT*, IU/L | |||
| ≤40 | 2036 (54.7) | 273 (12.0) | <.0001 |
| 41–60 | 896 (24.1) | 266 (11.7) | |
| >60 | 788 (21.2) | 1726 (76.2) | |
|
| |||
| Diabetes* | 622 (16.7) | 343 (15.1) | 0.11 |
|
| |||
| Alcohol* | 2218 (59.6) | 1319 (58.2) | 0.29 |
|
| |||
| Hypertension* | 2256 (60.6) | 1034 (45.6) | <.0001 |
|
| |||
| Low-HDL* | 2407 (64.7) | 1253 (55.3) | <.0001 |
|
| |||
| LDL (mean) | |||
| Initial value | 94 | 91 | <.0001 |
| Most recent value | 89 | 84 | |
|
| |||
| Initial LDL, mg/dL | |||
| <130 | 2688 (54.2) | 1541 (31) | <.0001 |
| 130–159 | 345 (7) | 184 (3.7) | |
| >160 | 136 (2.7) | 68 (1.4) | |
|
| |||
| Statin* | 767 (20.6) | 182 (8.0) | <.0001 |
|
| |||
| % Time on Statin at censor/cirrhosis | <.0001 | ||
| 0% | 2953 (79.4) | 2083 (92.0) | |
| >0–50% | 624 (16.8) | 147 (6.5) | |
| 51–100% | 143 (3.8) | 35 (1.5) | |
|
| |||
| Death | 892 (14.9) | 953 (15.9) | <.0001 |
*
Time-updated measurement