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. 2017 Jan 30;8:14011. doi: 10.1038/ncomms14011

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Copyright © 2017, The Author(s)

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(a) Schematic diagram highlighting the conserved architecture and domain composition of the SMC family of proteins. (b) Molecular-cartoon depiction of the S. pombe Smc5/6 heterodimeric hinge, indicating component subdomains, and North and South interfaces; see associated key for details. (c) Comparison of the hinge-domains of Smc5 and Smc6 with a prototypical SMC protein from T. maritima (PDB: 1GXL). (Left) Molecular-cartoon depictions coloured blue→red, from N→C-terminus. (Right) Cartoons coloured according to subdomain, connecting loops and linker regions; see associated key for details. Amino acid boundaries for Subdomain I, Subdomain II and inter-connecting linker region are indicated.