TABLE 2.
Comparison of pituitary tumor sizesa
| Measurement | Rb+/− K-ras+/+ mice at 280 days (n = 10) | Rb+/− K-ras+/− mice at 280 days (n = 8) | Rb+/− K-ras+/− mice at 360 days (n = 6) |
|---|---|---|---|
| Mean area (mm2) ± SD | 38.9b ± 9.6 | 21.6b ± 11.2 | 53.6 ± 12.0 |
| Range (minimum to maximum) | 12.0-51.2 | 11.2-44.8 | 19.2-61.2 |
a
Pituitary tumors were observed in mice with the indicated genotypes and ages. Tumor areas were determined under microscopy at the median section of tumors stained with H&E by measuring the longest diameter and its longest perpendicular line.
b
P = 0.029.