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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Addict Biol. 2016 Aug 3;22(6):1655–1664. doi: 10.1111/adb.12428

Fig 2.

Fig 2

OPRM1 Genotype Interacts with CSF levels of 5-HIAA to Predict High Intensity Aggression Following Alcohol Administration. Rhesus macaques were administered a binge dose of alcohol and provoked using a human intruder challenge test. Effects of OPRM1 genotype (C/C vs. G allele carrier) on aggressive response factors were assessed using ANOVA, with 5-HIAA and sex as a co-variables. A. There were effects of genotype on Escalated physical aggression, with G allele carriers exhibiting heightened aggression. B. Individuals with low 5-HIAA exhibited higher levels of High Intensity aggression if they were carriers of the 77G allele. There were no effects of sex or any genotype × sex or 5-HIAA × sex interactions.