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. 2017 Jan 31;8:14193. doi: 10.1038/ncomms14193

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(a) Antiplasmodial activity of 172 chronologically ordered amicarbalide derivatives against the P. falciparum strain Dd2. Substitutions on the West-side amidine group (grey), the benzamidine urea linker (green) and the East-side sulfonamide group (dark blue and red) are indicated. The two compounds SC81458 and SC83288 are highlighted. (b) Summary of the SAR analysis. Colour code as above.