Table 1. Relevant activity parameters of SC81458 and SC83288.

	SC81458	SC83288
IC50, IC90, IC99 (nM)	8, 18, 50	3, 8, 20
In vitro PCT99.9% (h)	37±4 (4)	51±6 (4)
In vitro logPRR	3.4±0.4 (4)	3.0±0.5 (4)
In vitro lag phase (h)	<5	<5
In vivo PCT99.9% (h)*	<48	48
In vivo logPRR*	5.3 (W2), 3.2 (3D7)	3.0

IC_50/90/99, inhibitory concentration of 50, 90 or 99% of the maximal effect; PCT_99.9%, clearance time of 99.9% of the original parasite population; PRR, parasite reduction ratio.

For the in vitro PCT_99.9% and the in vitro logPRR the means±s.e. of the means of (n) independent determinations are shown.

^*Obtained in the P. falciparum-infected humanized NSG mouse model system.