Table 1. Baseline CINRG natural history cohort analysis.

Phenotype	Overall P value	N: mean±s.d.	Post-hoc P values indicating significantly different means
10 Metre Walk Test (velocity m per sec)	0.0366	RR (N=16; 2.22±0.77)*	P=0.034*
		RX (N=29; 1.69±0.65)*
		XX (N=16; 1.79±0.54)
Grip QMT†	0.0228	RR (N=16; 4.02±0.66)*	P=0.019*
		RX (N=29; 3.43±0.60)*
		XX (N=16; 3.67±0.79)
Elbow extensor QMT†	0.0381	RR (N=16; 2.84±0.63)*	P=0.032*
		RX (N=27; 2.36±0.55)*
		XX (N=16; 2.54±0.57)
Elbow flexor QMT†	0.0641	RR (N=16; 3.10±0.56)	NONE
		RX (N=27; 2.68±0.60)
		XX (N=16; 2.77±0.52)
Knee extensor QMT†	0.0222	RR (N=16; 4.09±1.15)*	P=0.033*
		RX (N=27; 3.26±0.95)*
		XX (N=16; 3.24±0.93)
Knee flexor QMT†	0.0384	RR (N=16; 3.72±0.43)*	P=0.0384*
		RX (N=27; 3.32±0.51)*
		XX (N=16; 3.54±0.54)

One-way ANOVA, Šidák adjustment for multiple comparisons.*denotes genotype groups compared to give the P value shown in column 4.

^†Square root transformed variable.