. 2016 Dec 13;6(12):e978. doi: 10.1038/tp.2016.241

Table 1. The relationship between ADCYAP1R1 expression and rs2267735 genotype, estradiol and PTSD symptoms in whole-blood mRNA from study participants.

A	N	High ADCYAP1R1 expression	Low ADCYAP1R1 expression
All genotypes
Low serum estradiol (range : 5.70–32.74 pg ml⁻¹)	48	39.6% (N=19)	60.4% (N=29)
High serum estradiol (range: 33.84–528.35 pg ml⁻¹)	47	61.7% (N=29)	38.3% (N=18)
	Pearson χ², P=0.031

B	N	Mean ADCYAP1R1 ΔCt	s.d.
Lower quartile of estradiol (E2)
rs2267735 genotype
GG or GC (E2 range: 5.70–14.75 pg ml⁻¹)	14	20.86	1.61
CC (E2 range: 5.70–15.0 pg ml⁻¹)	10	22.02	0.86
	Two-tailed t-test, P=0.049

C	N	High ADCYAP1R1 expression	Low ADCYAP1R1 expression
CC genotypes only
Low serum estradiol (range: 5.70–32.74 pg ml⁻¹)	23	30.4% (N=7)	69.6% (N=16)
High serum estradiol (range: 41.91–269.31 pg ml⁻¹)	19	63.2% (N=12)	36.8% (N=7)
	Pearson χ², P=0.034

D	N	Mean PTSD symptoms	s.d.
High ADCYAP1R1 expression	48	7.97	9.22
Low ADCYAP1R1 expression	47	12.38	9.77
	Two-tailed t-test, P=0.026

Abbreviations: mRNA, messenger RNA; PTSD, posttraumatic stress disorder.