Table 1. Relationships between molecular parameters and composite cognitive scores and neuroanatomical measures outcome variables for the PM group.
| Outcome variables | β (r2) |
|||||||
|---|---|---|---|---|---|---|---|---|
| CGG | AR | FMR1 mRNA | CpG 1 | CpG 2 | CpG 6/7 | CpG 8/9 | CpG 10–12 | |
| Prosaccade response time | −0.142 (0.020) | 0.450 (0.199) | 0.288 (0.093) | −0.105 (0.011) | 0.232 (0.054) | 0.791 (0.366) | 0.321 (0.103) | 0.281 (0.064) |
| Prosaccade error score | 0.217 (0.047) | −0.469 (0.350) | 0.038 (0.001) | 0.364 (0.261) | −0.253 (0.064) | −0.76 (0.353) | −0.591 (0.344) | −0.670 (0.478) |
| Executive function score | 0.229 (0.053) | −0.196 (0.009) | 0.132 (0.017) | 0.010 (0.000) | 0.213 (0.045) | −0.455 (0.198) | −0.511 (0.261) | −0.310 (0.086) |
| White matter hypointensities | −0.079 (0.006) | 0.386 (0.158) | 0.265 (0.100) | −0.511 (0.261) | 0.113 (0.013) | 0.471 (0.222) | 0.076 (0.005) | 0.405 (0.079) |
| Left middle frontal gyrus | −0.146 (0.021) | 0.215 (0.051) | −0.254 (0.066) | 0.106 (0.011) | 0.331 (0.109) | 0.427 (0.179) | 0.564 (0.319) | 0.504 (0.220) |
| Right middle frontal gyrus | 0.035 (0.001) | 0.039 (0.002) | −0.346 (0.116) | 0.065 (0.004) | 0.055 (0.003) | 0.250 (0.062) | 0.655 (0.430) | 0.375 (0.117) |
| Left superior frontal gyrus | −0.024 (0.001) | −0.051 (0.003) | −0.324 (0.104) | 0.252 (0.064) | 0.292 (0.085) | 0.426 (0.176) | 0.541 (0.293) | 0.455 (0.183) |
| Right superior frontal gyrus | 0.030 (0.001) | 0.065 (0.005) | −0.186 (0.033) | 0.305 (0.093) | 0.276 (0.076) | 0.293 (0.086) | 0.612 (0.374) | 0.415 (0.168) |
| Left inferior parietal gyrus | −0.081 (0.007) | −0.200 (0.040) | −0.294 (0.084) | 0.058 (0.003) | 0.104 (0.011) | 0.558 (0.312) | 0.494 (0.241) | 0.317 (0.077) |
| Right inferior parietal gyrus | −0.020 (0.000) | −0.242 (0.056) | −0.350 (0.119) | −0.039 (0.002) | 0.052 (0.003) | 0.242 (0.045) | 0.089 (0.008) | −0.023 (0.000) |
Abbreviations: β, standardized regression coefficients; AR, activation ratio; FMR1, Fragile X mental retardation 1; PM, premutation; r2, coefficient of determination.
Note: Figures in bold indicate that P<0.05.