Table 2. Relationships between molecular parameters and composite cognitive scores and neuroanatomical measure outcome variables for the healthy control group.
| Outcome variables | β (r2) |
|||||||
|---|---|---|---|---|---|---|---|---|
| CGG | AR | FMR1 mRNA | CpG 1 | CpG 2 | CpG 6/7 | CpG 8/9 | CpG 10–12 | |
| Prosaccade response time | −0.249 (0.062) | −0.353 (0.125) | 0.475 (0.225) | 0.148 (0.020) | −0.267 (0.067) | 0.087 (0.008) | 0.075 (0.006) | −0.054 (0.003) |
| Prosaccade error score | 0.109 (0.018) | −0.011 (0.000) | −0.282 (0.190) | 0.032 (0.002) | 0.296 (0.159) | 0.314 (0.099) | 0.153 (0.023) | 0.205 (0.042) |
| Executive function score | 0.201 (0.040) | 0.248 (0.061) | −0.402 (0.162) | 0.152 (0.023) | 0.089 (0.009) | 0.016 (0.000) | −0.330 (0.109) | −0.164 (0.027) |
| White matter hypointensities | −0.426 (0.206) | −0.254 (0.074) | 0.360 (0.130) | 0.105 (0.011) | 0.271 (0.071) | 0.418 (0.174) | 0.429 (0.184) | 0.206 (0.042) |
| Left middle frontal gyrus | 0.117 (0.010) | −0.271 (0.074) | −0.158 (0.025) | −0.015 (0.000) | −0.588 (0.334) | −0.651 (0.424) | −0.466 (0.217) | −0.621 (0.386) |
| Right middle frontal gyrus | 0.133 (0.014) | −0.280 (0.078) | −0.084 (0.006) | −0.124 (0.015) | −0.151 (0.021) | −0.293 (0.086) | −0.045 (0.002) | −0.261 (0.068) |
| Left superior frontal gyrus | −0.454 (0.063) | −0.212 (0.045) | −0.306 (0.093) | 0.253 (0.030) | −0.022 (0.000) | −0.378 (0.143) | −0.119 (0.014) | −0.728 (0.302) |
| Right superior frontal gyrus | 0.164 (0.021) | −0.297 (0.088) | −0.259 (0.067) | −0.076 (0.005) | −0.085 (0.007) | −0.507 (0.257) | −0.175 (0.031) | −0.521 (0.166) |
| Left inferior parietal gyrus | 0.098 (0.008) | −0.269 (0.072) | −0.293 (0.086) | −0.349 (0.132) | −0.006 (0.000) | −0.426 (0.182) | −0.076 (0.006) | −0.302 (0.079) |
| Right inferior parietal gyrus | −0.433 (0.056) | −0.052 (0.002) | −0.340 (0.115) | −0.081 (0.005) | 0.060 (0.004) | −0.043 (0.002) | −0.310 (0.087) | −0.301 (0.078) |
Abbreviations: β, standardized regression coefficients; AR, activation ratio; FMR1, Fragile X mental retardation 1; r2, coefficient of determination.
Note: Figures in bold indicate that P<0.05.