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. 2016 Oct 25;6(10):e927. doi: 10.1038/tp.2016.189

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Copyright © 2016 The Author(s)

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Propionic acid (PPA) enhances mitochondrial function in autistic lymphoblastoid cell lines (LCLs) over and above the effect it has on control LCLs in a concentration and exposure time-dependent manner. ATP-linked respiration, maximal respiratory capacity and reserve capacity were enhanced over and above control values at 0.1 mM for the autistic disorder with normal mitochondrial function (AD-N) LCLs with 24 h PPA incubation (a, c, d), whereas all of these mitochondrial parameters were enhanced at 0.1 and 1 mM for the autistic disorder with abnormal mitochondrial function (AD-A) LCLs with 48-h PPA incubation (e, g, h). Proton leak respiration was also significantly increased above control values for the autistic LCLs as compared with controls (b, f). The bars adjacent to the data lines represent overall significant differences. The color of the stars and bars represents the specific comparisons. Green represents the difference between AD-A and Control LCLs. Orange represents the difference between AD-N and Control LCLs. Blue represents the difference between the AD-N and AD-A LCLs. Statistical significance levels: *P⩽0.05, **P⩽0.01, ***P⩽0.001, ****P⩽0.0001.