Table 2. Anterior cingulate metabolite and voxel tissue proportion means (s.d.) in the schizophrenia and control groups.

	Schizophrenia (n=27)	Control (n=29)	Statistic (F)	P
MRS metabolites (IU)
Glutamate	7.9 (0.85)	8.1 (0.67)	0.23	0.63
Glutamine	1.9 (0.28)	1.8 (0.36)	5.1	0.028
Glutamine/glutamate	0.25 (0.04)	0.22 (0.05)	5.7	0.021a
Lactate	0.59 (0.18)	0.49 (0.09)	4.4	0.045a
GABA	1.6 (0.21)	1.7 (0.18)	1.1	0.31
n-acetylaspartate	7.6 (0.67)	7.8 (0.44)	2.2	0.14
NAAG	0.64 (0.14)	0.67 (0.15)	0.23	0.64
Glycerophosphocholine+phosphocholine	1.6 (0.20)	1.5 (0.16)	1.3	0.27
Creatine	3.6 (0.40)	3.5 (0.43)	0.39	0.53
Phosphocreatine	2.3 (0.35)	2.4 (0.30)	0.32	0.57
Myo-inositol	5.8 (0.64)	5.8 (0.42)	0.23	0.63
Taurine	1.3 (0.27)	1.3 (0.21)	0.46	0.50
Serine	1.4 (0.34)	1.4 (0.47)	1.02	0.32
Aspartate	1.4 (0.22)	1.5 (0.16)	0.99	0.33
Glutathione	1.5 (0.16)	1.5 (0.11)	0.16	0.69
MRS voxel (%)
CSF	11.0 (3.6)	10.6 (3.9)	-0.42	0.68
White matter	19.2 (6.1)	18.1 (3.7)	-0.83	0.41
Gray matter	69.8 (5.4)	71.3 (3.6)	1.23	0.22

Abbreviations: CSF, cerebrospinal fluid; GABA, gamma-aminobutyric acid; IU, institutional unit; MRS, magnetic resonance spectroscopy; NAAG, n-acetylaspartylglutamate.

^aStatistically significant.