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. 2017 Feb 3;8:23. doi: 10.3389/fphar.2017.00023

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Copyright © 2017 Rouleau, Audet-Delage, Desjardins, Rouleau, Girard-Bock and Guillemette.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UGT1A interaction network in drug metabolizing tissues. UGT1A interacting proteins were classified according to KEGG pathways with ClueGO/CluePedia (Bindea et al., 2009, 2013). Node size is representative of pathway enrichment significance. Interactome was enhanced with significant interaction partners not part of KEGG pathways that are functionally related based on Uniprot and literature. These proteins are not linked to nodes but are grouped according to global functions. Structural proteins, ribosomal protein subunits and other RNA-binding proteins involved in mRNA splicing are not shown but were significantly enriched in UGT1A IPs. Full protein names are provided in Table 2. Complete lists of UGT1A interacting proteins are provided in Supplementary Table 2.