Table 1.
Top 10 UGT1A interaction partnersa for each tissue based on confidence score.
| Liver | Kidney | Intestine | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Protein nameb | Coverage (%)c | Total spectral countsd | FC_B score | Protein nameb | Coverage (%)c | Total spectral countsd | FC_B score | Protein nameb | Coverage (%)c | Total spectral countsd | FC_B score |
| PHKB | 36 | 193 | 28.55 | TOP2B | 16 | 53 | 5.93 | ATP5A1 | 13 | 8 | 4.91 |
| PHKA2 | 34 | 180 | 26.62 | PFKL | 24 | 35 | 4.68 | UGT2A3 | 24 | 61 | 4.63 |
| PHKG2 | 40 | 68 | 10.49 | TRA2B | 24 | 36 | 4.21 | GBF1 | 12 | 60 | 4.60 |
| PRDX2 | 47 | 55 | 7.62 | ATP5A1 | 33 | 32 | 4.10 | SLC25A5 | 35 | 54 | 4.37 |
| UGT2B7 | 19 | 31 | 5.53 | PRDX2 | 41 | 50 | 3.60 | RALGAPB | 13 | 51 | 4.26 |
| PRDX1 | 35 | 25 | 3.42 | PRDX1 | 44 | 39 | 3.08 | PRDX2 | 24 | 46 | 4.06 |
| ECH1 | 28 | 17 | 2.61 | HSPA8 | 30 | 21 | 2.70 | PRDX1 | 31 | 45 | 4.01 |
| SLC25A5 | 17 | 9 | 2.20 | SLC34A2 | 16 | 17 | 2.66 | RALGAPA2 | 6 | 29 | 3.28 |
| GBF1 | 4 | 9 | 2.15 | ACCA2 | 43 | 21 | 2.30 | ECH1 | 30 | 21 | 2.84 |
| UGT2B4 | 11 | 12 | 1.98 | ASS1 | 42 | 21 | 2.22 | PDIA3 | 5 | 3 | 2.82 |
a
Excluding common IP protein contaminants (structural, ribosomal and RNA-binding proteins).
b
Proteins in bold were identified in the 3 tissues.
c
Total coverage calculated with peptides identified in all replicates (n = 4, 3 and 2 for the liver, kidney and intestine, respectively).
d
Total spectral counts of all replicates.