Table 2.
Genotype and allelic frequencies of β-fibrinogen C148T gene polymorphism in IS patients and controls
| Group | Subjects, n | Genotypes, n (%) |
HWE p value | Allele, n (%) |
Allele C vs. T |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | C | T | OR | 95% CI | p value | |||
| Controls | 250 | 188 (75.2) | 56 (22.4) | 6 (2.4) | 0.45 | 432 (86.4) | 68 (13.6) | |||
| IS | 250 | 153 (61.2) | 90 (36) | 7 (2.8) | 0.14 | 396 (79.2) | 104 (20.8) | 1.66 | 1.19–2.33 | 0.002 |
| LVD | 107 | 67 (62.6) | 39 (36.4) | 1 (0.94) | 0.06 | 173 (80.8) | 41 (19.1) | 1.50 | 0.98–2.30 | 0.058 |
| SVD | 83 | 50 (60.2) | 30 (36.1) | 3 (3.7) | 0.55 | 130 (78.3) | 36 (21.7) | 1.75 | 1.12–2.75 | 0.01 |
| CE | 26 | 15 (57.7) | 9 (34.6) | 2 (7.7) | 0.69 | 39 (75) | 13 (25) | 2.11 | 1.07–4.17 | 0.02 |
| Others | 34 | 21 (61.8) | 12 (35.3) | 1 (2.9) | 0.64 | 54 (79.4) | 14 (20.6) | 1.64 | 0.86–3.12 | 0.12 |
CI = Confidence interval; OR = odds ratio; C = cytosine; CC = cytosine cytosine; T = thymine; CT = cytosine thymine; TT = thymine thymine; IS = Ischemic stroke; LVD = large vessel disease; SVD = small vessel disease; CE = cardioembolic; HWE = Hardy-Weinberg equilibrium. Boldface denotes significance (p < 0.05).