Table 3. Differentially expressed precursor microRNA in the CD4+ cell population.
| Probe set | Symbol | Entrez | Location | Probes | P-value | Fold-change |
|---|---|---|---|---|---|---|
| TC17000728.hg.1 | hsa-mir-21 | 406991 | chr17 (q23.1) | 30 | 4.18E-07 | 4.376 |
| TC17001729.hg.1 | hsa-mir-142 | 406934 | chr17 (q22) | 30 | 1.18E-05 | 2.204 |
| TC02001872.hg.1 | hsa-mir-216b | 100126319 | chr2 (p16.1) | 30 | 8.72E-08 | −2.093 |
| TC12000573.hg.1 | hsa-mir-548c | 693129 | chr12 (q14.2) | 30 | 7.24E-05 | 2.731 |
| TC07000452.hg.1 | hsa-mir-590 | 693175 | chr7 (q11.23) | 30 | 4.21E-05 | 2.641 |
| TC10000348.hg.1 | hsa-mir-605 | 693190 | chr10 (q21.1) | 30 | 8.41E-07 | −2.058 |
| TC20000241.hg.1 | hsa-mir-644a | 693229 | chr20 (q11.22) | 30 | 7.74E-08 | 3.846 |
| TC04001648.hg.1 | hsa-mir-3140 | 100422896 | chr4 (q31.3) | 30 | 2.25E-05 | 2.083 |
| TC10000815.hg.1 | hsa-mir-4295 | 100422909 | chr10 (q25.2) | 30 | 1.08E-05 | 2.037 |
| TC02000369.hg.1 | hsa-mir-4434 | 100616419 | chr2 (p14) | 10 | 1.24E-04 | 2.259 |
| TC05000673.hg.1 | hsa-mir-4461 | 100616209 | chr5 (q31.1) | 30 | 2.13E-04 | −2.055 |
| TC09000561.hg.1 | hsa-mir-4668 | 100616114 | chr9 (q31.3) | 25 | 1.27E-05 | 2.051 |
This table shows 12 precursor miRNA that were identified as more abundant (n = 9) or less abundant (n = 3) after 3 months of fingolimod treatment in comparison to baseline (p-value < 0.001 and fold-change > + 2.0 or <−2.0). For each miRNA stem-loop, the table provides the miRBase database symbol, the Entrez database identifier, the genomic location, the Affymetrix HTA 2.0 probe set and the number of probes on the microarrays that were used to quantify the expression.