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. 2017 Feb 3;7:41980. doi: 10.1038/srep41980

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(a) The metaphase is from PPY-10, heterozygous for the ENC12, hybridized with a pool of alphoid centromeric sequences obtained as described in Methods (red signal). The short arrow indicates the normal PPY12, while the long one points to the ENC12 chromosome. (b) The partial metaphase is from the PPY-15 homozygous. The two ENC12 chromosomes (arrowed) show the FISH signal of the centromeric alphoid sequences (red) at the old deactivated centromere and the immuno signal (green) at the functional ENC12 centromere. The immuno signal was obtained using antibodies against the centromeric protein CENP-C.