Figure 4. Platelet transfusion attenuates ECC-induced pulmonary inflammation.

Mice were subjected to ECC for 30 min, treated as described in the legend to Fig. 2, and then the right lung was harvested 1 h later, homogenized, and centrifuged. Samples were assayed for TNF-α (A), neutrophil elastase (B), and TGF-β (C) using commercial ELISA kits. Levels of TGF-β correlated negatively with TNF-α (D) and with neutrophil elastase (E). Data shown are mean ± SEM.