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The Polqchaos1 allele enhances chromosome instability in MEFs
| Parameter | Result with Atm, Polqchaos1 genotypes:
|
|||
|---|---|---|---|---|
| +/+, +/− | +/+, −/− | −/−, +/− | −/−, −/− | |
| No. of metaphases | 26 | 27 | 26 | 25 |
| No. of chromatid gaps | 1 | 8 | 15 | 21 |
| No. of chromatid breaks | 1 | 3 | 30 | 46 |
| No. of chromosome breaks | 0 | 1 | 4 | 12 |
| No. of other abnormalities (including translocations) | 0 | 0 | 3 | 4 |
| Total no. of abnormalities | 2 | 12 | 52 | 83 |
| % Cells with abnormalities | 7.7 | 37.0 | 88.5 | 84.0 |
| No. of abnormalities per cell | 0.08 | 0.44 | 2.0 | 3.32 |
