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. 2004 Dec;24(23):10416–10424. doi: 10.1128/MCB.24.23.10416-10424.2004

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Copyright © 2004, American Society for Microbiology

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FIG. 4. — Cell and stage specificity of EKLF transrepression. (A) Transrepression by wild-type GAL/EKLF was tested in K562 (human fetal-type erythroid), NIH 3T3 (murine nonerythroid), and MEL (murine adult-type erythroid) cells and compared to basal levels of reporter activity after cotransfection with GAL 1-147. Chloramphenicol acetyltransferase (CAT) activity in extracts was normalized to cotransfected growth hormone. (B) HOX11-immortalized erythroid cells (EBHX11) growing in LIF (11L; left panel) or Epo (llE; right panel) were transfected with pG5tkCAT and GAL 1-147 or GAL/EKLF. The statuses of embryonic (βh1) and adult (βmaj) globins in these two cell lines are indicated below each panel. Chloramphenicol acetyltransferase activity in extracts was normalized to cotransfected growth hormone.