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. 2017 Feb 2;10:40. doi: 10.1186/s13045-017-0406-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Cooperation analysis shows that among the 7 caspase-1 and IL-1β globally regulated genes with >2 fold change, caspase-1 and IL-1β cooperatively regulate 6 genes (85.7%). a FC/FC plot comparing log2 transformed fold changes (Log2 FC) of genes for meta-Caspase-1 (deletion of Caspase-1 among six different tissues) vs. wild type (x-axis) and parallel meta-IL-1β (meta-analysis of treatment and transgenic IL-1β) vs. control (y-axis). b Significantly changed genes with fold changes higher than two among the four quadrants. c Further analysis by Ingenuity Pathway revealed the top five signatures of the genes regulated by caspase-1 with cooperation of IL-1β. d The top five signatures of the genes that are regulated by caspase-1 non-cooperatively with IL-1β (p < 0.05)