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. 2017 Feb 2;18:84. doi: 10.1186/s12859-017-1501-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — An example of one round of simulation results (simulation 316) comparing calculated RSD for metabolites in QC and analytical samples before normalization (open circles) and RSD after normalization for four different methods (closed circles) v. true RSD prior to inclusion of batch effects and batch-specific detection thresholds in the simulation. Points are colored according to the proportion of undetected levels in the simulation for that metabolite. The black line indicates perfect correspondence of true and estimated RSD