Table 2.
Number and incidence rate of CVD, all-cause mortality and composite of CVD and all-cause mortality among estimated glomerular filtration rate (eGFR) groups by multivariable Cox proportional hazard regression
| eGFR Group 1 (≥90 ml/min/1.73 m2) (N = 100,785) |
eGFR Group 2 (60–89 ml/min/1.73 m2) (N = 38,537) |
eGFR Group 3 (30–59 ml/min/1.73 m2) (N = 7,067) |
eGFR Group 4 (15–29 ml/min/1.73 m2) (N = 431) |
eGFR Group 5 (<15 ml/min/1.73 m2) (N = 133) |
|
|---|---|---|---|---|---|
| CVD | |||||
| Cumulative Cases with Event | 5,552 | 4,426 | 1,404 | 134 | 38 |
| Cumulative Incidence Rate | 5.5% | 11.5% | 19.9% | 31.1% | 28.6% |
| Person-years | 4,925,567 | 1,823,869 | 301,183 | 12,069 | 2,871 |
| Medium follow-up (Months) | 51.5 | 50.5 | 47.5 | 24.5 | 14.5 |
| Incidence Rate (95% CI) a | 13.53 (13.18,13.89) | 29.12 (28.28,29.99) | 55.94 (53.09,58.94) | 133.24 (112.49,157.82) | 158.86 (115.59,218.32) |
| Hazard Ratio (95% CI) | Reference group | 1.17* (1.12,1.22) | 1.63* (1.52,1.73) | 3.17* (2.66,3.78) | 4.55* (3.29,6.31) |
| All-cause mortality | |||||
| Cumulative Cases with Event | 4,416 | 3,512 | 1,546 | 252 | 90 |
| Cumulative Incidence Rate | 4.4% | 9.1% | 21.9% | 58.5% | 67.7% |
| Person-years | 5,041,933 | 1,910,744 | 325,858 | 13,944 | 3,166 |
| Medium follow-up (Months) | 51.5 | 51.5 | 49.5 | 35.5 | 16.5 |
| Incidence Rate (95% CI)a | 10.51 (10.20,10.82) | 22.06 (21.34,22.80) | 56.93 (54.16,59.84) | 216.88 (191.69,245.38) | 341.18 (277.50,419.47) |
| Hazard Ratio (95% CI) | Reference group | 0.99 (0.95,1.04) | 1.70* (1.59,1.81) | 5.19* (4.55,5.93) | 9.49* (7.68,11.73) |
| Composite of CVD and mortality | |||||
| Cumulative Cases with Event | 9,062 | 6,817 | 2,374 | 287 | 96 |
| Cumulative Incidence Rate | 9.0% | 17.7% | 33.6% | 66.6% | 72.2% |
| Person-years | 4,925,567 | 1,823,869 | 301,183 | 12,069 | 2,871 |
| Medium follow-up (Months) | 51.5 | 50.5 | 47.5 | 24.5 | 14.5 |
| Incidence Rate (95% CI)a | 22.08 (21.63,22.54) | 44.85 (43.80,45.93) | 94.59 (90.86,98.47) | 285.37 (254.19,320.37) | 401.32 (328.56,490.20) |
| Hazard Ratio (95% CI) | Reference group | 1.03 (1.00,1.07) | 1.51* (1.44,1.58) | 4.09* (3.63,4.62) | 7.08* (5.78,8.68) |
Hazard ratios were adjusted for age, gender, smoking status, drinking habit, body mass index, waist-to-hip ratio, glycated hemoglobin A1c, systolic and diastolic blood pressure, low-density lipoprotein-cholesterol, total cholesterol to high-density lipoprotein cholesterol ratio, triglyceride, urine albumin/creatinine ratio, self-reported duration of diabetes mellitus, family history of diabetes mellitus, diagnosed hypertension, the usage of anti-hypertensive drugs, oral anti-diabetic drugs, insulin and lipid-lowering agents at baseline
CVD Cardiovascular Diseases, eGFR estimated Glomerular Filtration Rate
*Significant difference (P < 0.05) by multivariable Cox proportional hazards regression
aIncidence rate (cases/1000 person-years) with 95%CI based on Poisson distribution