Comparison of the proteins ORF1 (A), ORF2 (B), and ORF3 (C) with proteins in databases. The numbers refer to the positions of the amino acids. A. Highly similar sequences are marked in black, and sequences with weak or no similarities are in white. Dark grey indicates an extended conserved region in the proteins of T. aromatica, B. subtilis, and G. metallireducens, and light grey indicates an additional sequence similarity between the proteins of T. aromatica and G. metallireducens. H marks a conserved histidine residue in all four proteins. Striping (B) and cross-hatching (C) indicate sequence similarities. For details, see Discussion. CBS, cystathionine-β-synthase; PEPS, PEP synthase.