Table 5.
The conditions of children from the same parents with two or more pregnancies
| Patient | 1. Pregnancy AED (mg/day) | Malformation | 2. Pregnancy AED (mg/day) | Malformation | 3. Pregnancy AED (mg/day) | Malformation |
|---|---|---|---|---|---|---|
| 1 | CBZ 100 | - | CBZ 100 | PFO | ||
| 2 | CBZ 800 | Teeth | CBZ 800 | Teeth | ||
| 3 | CBZ 200+VPA 500 | - | CBZ 200 | PFO | ||
| 4 | CBZ 300 | - | CBZ 600 | - | ||
| 5 | VPA 500 | Dilatation in pericalyxial system | VPA 500 | - | ||
| 6 | VPA 2,000 | Strabismus | VPA 2,000 | Strabismus | ||
| 7 | VPA 1,000 | - | VPA 1,000 | - | ||
| 8 | VPA 600 | - | VPA 200 | - | ||
| 9 | VPA 1,500 | Teeth | VPA 1,000 | - | ||
| 10 | VPA 500 | Teeth | VPA 500 | - | VPA 500 | - |
| 11 | PB 200 | Teeth | VPA 500 | - | ||
| 12 | PB 100 | Teeth | PB 300 | Teeth | ||
| 13 | PHT 300 | Teeth | PHT 150+PB 150 | Hydronephrosis | ||
| 14 | OXC 1,000 | PFO | OXC 1,000 | - | ||
| 15 | CLZ 0.5 | Teeth | CLZ 0.5 | Teeth | ||
| 16 | PB 25 | - | Non-AED | PFO | ||
| 17 | CBZ 300+PB 300+PHT 300 | Teeth | CBZ 300+PB 300 +PHT 100 | Teeth+PFO+ASD+ left persistant superior vena cava* | CBZ 200+PB 300 +PHT 100 | Teeth |
| 18 | Non-AED | Renal agenesis | VPA 1,000 | Renal agenesis | ||
| 19 | Non-AED | - | Non-AED | VSD | Non-AED | - |
| 20 | Non-AED | - | Non-AED | Left intraventricular band/t | ||
| 21 | Non-AED | - | VPA 500 | Syndactyly | ||
| 22–25 | Non-AED | - | Non-AED | - | ||
| 26 | Non-AED | - | Non-AED | - | Non-AED | - |
AED, antiepileptic drug; CBZ, carbamazepine; VPA, valproic acid; PB, phenobarbital; PHT, phenytoin; OXC, oxcarbazepine; CLZ, clonazepam; PFO, patent foramen ovale; ASD, atrial septal defect; VSD, ventricular septal defect.