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. 2016 Dec 20;292(5):1573–1590. doi: 10.1074/jbc.M116.769430

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FIGURE 2. — Evolution of LDLc concentration of patient III-3 following different therapies and family pedigree. A, LDLc concentrations following several lipid-lowering treatments. B, family pedigree. The prepositus is marked with an arrow. Round symbols, females. Square symbols, males. Black outlined symbols, family members for which data were available. Gray outlined symbols, family members for which no data were available. Symbols crossed through: deceased individuals. LDLR-R410S allele, dark gray shading. LDLR-G592E allele, light gray shading.