TABLE 2.
Average characteristics of the untreated subjects in each mutation group
TC is total cholesterol; HDLc is high density lipoprotein cholesterol; LDLc is low density lipoprotein cholesterol; TG is triglyceride. The numbers are listed as averages (± S.D. from the mean).
| Genotype | No. of subjects | Age | Sex, male/female | TC | HDLc | LDLc | TG | PCSK9 |
|---|---|---|---|---|---|---|---|---|
| years | mmol/liter | ng/ml | ||||||
| R410S/G592E | 1 | 23 | 1/0 | 11.5 | 0.8 | 10.2 | 1.0 | 82.0 |
| R410S/WT | 2 | 63.5 (± 16.3) | 1/1 | 7.8 (± 2.1) | 1.2 (± 0.1) | 5.9 (± 0.3) | 1.6 (± 0.3) | 90.5 (± 23.3) |
| WT/G592E | 2 | 63.5 (± 16.3) | 1/1 | 7.3 (± 1.2) | 1.3 (± 0.1) | 5.3 (± 0.3) | 1.5 (± 0.4) | 81.5 (± 2.1) |
| WT/WT | 8 | 38.2 (± 18.8) | 3/5 | 5.4 (± 1.3) | 1.3 (± 0.2) | 3.4 (± 1.4) | 1.4 (± 1.2) | 84.1 (± 24.5) |