FIGURE 6.

Reduced delivery of BACE1 to somatic lysosomes in mutant hAPP Tg mouse brains. A–C, representative images (A) and quantitative analysis (B and C) showing reduced lysosomal delivery of BACE1 in the soma of the hippocampal CA3 regions in mutant hAPP Tg mice. The mean intensities of BACE1 fluorescence and BACE1 co-localization with LAMP-1 in the soma were quantified, respectively. Data were quantified from a total number of imaging slice sections (320 μm × 320 μm) indicated on the top of bars (B and C). Scale bars, 10 μm. Error bars, S.E. Student's t test. (***, p < 0.001.)